Structural Bioinformatics (Methods of Biochemical Analysis) - Hardcover

Hardcover

ISBN 10: 0471202002 ISBN 13: 9780471202004

Publisher: Wiley–Blackwell, 2003

Synopsis

From the Foreword: "[A] must read for all of us committed to understanding the interplay of structure and function...[T]he individual chapters outline the suite of major basic life science questions, such as the status of efforts to predict protein structure and how proteins carry out cellular functions, and also the applied life science questions such as how structural bioinformatics can improve health care through accelerating drug discovery." This book provides a basic understanding of the theories, associated algorithms, resources, and tools used in structural bioinformatics. The reader emerges with the ability to make effective use of protein, DNA, RNA, carbohydrate, and complex structures to better understand biological function. Moreover, it draws a clear connection between structural studies and the rational design of new therapies.

About this title

About the Author

PHILIP E. BOURNE, PhD, is a professor in the Department of Pharmacology at the University of California, San Diego, and Director of Integrated Biosciences at the San Diego Supercomputer Center. He is also President of the International Society for Computational Biology (ISCB). Dr. Bourne is the author of over 100 peer--reviewed scientific papers and three previous books. HELGE WEISSIG, PhD, is a Project Leader in Bioinformatics at ActivX Biosciences, a proteomics company, and also co--coordinates the Bioinformatics Certificate program for UCSD Extension. After doing his postdoctoral work with Professor Bourne at the San Diego Supercomputer Center, he became the Technical Project Manager for the RCSB Protein Data Bank (PDB) at UCSD.

From the Back Cover

"This collection . . . is a must-read for all of us committed to understanding the interplay of structure and function . . . [T]he individual chapters outline the suite of major basic life science questions such as the status of efforts to predict protein structure and how proteins carry out cellular functions, and also the applied life science questions such as how structural bioinformatics can improve health care through accelerating drug discovery."

-From the Foreword by John C. Wooley

As genomic and post-genomic innovations revolutionize the biological sciences, three-dimensional structural data continues to prove of vital importance to understanding function. Structural Bioinformatics represents an unprecedented, comprehensive account of the state of the discipline, providing an essential resource for students and practitioners.

Philip Bourne and Helge Weissig's authoritative text delivers a basic understanding of the theories, associated algorithms, resources, and tools used in structural bioinformatics. Among other topics, the book covers:

*Fundamentals of protein structure

*X-ray crystallography

*Molecular visualization

*Structure classification of proteins (SCOP)

*Class, architecture, topology, and homology (CATH) classification

*Proteins as drug targets

Practicing researchers as well as students in biology, medicine, and computer science will find Structural Bioinformatics to be this field's premier resource.

From the Inside Flap

The emerging discipline of structural bioinformatics comprises the development of computational technologies for methods of storage, retrieval, and analysis of the three-dimensional structure of biological macromolecules. Edited by Philip Bourne and Helge Weissig, this groundbreaking text provides a thorough understanding of the theories, associated algorithms, resources, and tools used in structural bioinformatics.

Structural Bioinformatics begins with chapters on the fundamentals of protein structure, DNA/RNA structure, carbohydrates, and techniques including X-ray crystallography, NMR, cryo-electron microscopy, and molecular visualization. The next section addresses data representation and databases, followed by information on structure classification of proteins (SCOP) and class, architecture, topology, and homology (CATH) classification. Later chapters cover structure-function assignment, protein interactions, and proteins as drug targets. Structural Bioinformatics also:

• Covers the theory, biology, resources, and practical applications for computational approaches to biomolecular structural studies
• Provides broad-based, concise coverage with a consistent direction
• Offers detailed coverage for practitioners while remaining accessible to the novice
• Presents computational analysis of growing masses of structural data as the key to advances in pharmacogenomics

The book concludes with several chapters on structure prediction methods, and discussion of the future of high-throughput structure determination in drug design.

Readers will gain the ability to make effective use of protein, DNA, RNA, carbohydrate, and complex structures to better understand biological function. Molecular biologists, biochemists, biophysicists, and bioinformaticians in basic and clinical research, as well as undergraduate and graduate students in biology, medicine, and computer science, will find Structural Bioinformatics to be an essential addition to their professional and academic libraries.

Edition details

• Publisher: Wiley–Blackwell
• Publication date: 2003
• ISBN 10: 0471202002
• ISBN 13: 9780471202004
• Binding: Hardcover
• Language: English
• Number of pages: 650
• Editor: Bourne Philip E., Weissig Helge