Molecular and Cell Biology of Human Gene Therapeutics (Molecular and Cell Biology of Human Diseases Series)

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9780412625503: Molecular and Cell Biology of Human Gene Therapeutics (Molecular and Cell Biology of Human Diseases Series)
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advanced metastatic disease of solid tumors, dictates that each tumor mass, indeed each individual metastasis, will have a unique antigen and cytokine environment and hence unique response to immune modu­ lation. A differential response to immunotherapy is thus inevitable. 4. Many of the human trials described are not randomized and report survival or response against historical controls. Most tumors described are immunogenic human tumors: renal cell cancer and melanoma are most common. In order to avoid the well-described inter-patient vari­ ation and rare incidence of spontaneous response among patient samples as well as selection bias and changes in practice over time, randomized trials are required. 5. Immunological treatment is unlike conventional chemotherapy in its endpoint. Most chemotherapeutic regimes require a complete response or a good partial response for cure or good palliation. There are now many cases where immunotherapy has provided long-term palliation without massive tumor reduction. Immunity may be stimulated to a degree which holds tumorigenicity in check and most importantly, pro­ vides good palliation for the patient in a manner that differs essentially from chemotherapy.

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Written to inform not only basic research scientists and students, but also practising physicians, this volume reviews the evolution of gene transfer as a therapeutic strategy. The latest developments in viral and non-viral vectors for gene therapy are explained. The book then moves on to describe gene therapy applications in a comprehensive range of disease situations including cancer, AIDS, arthritis, cardiovascular and neuromuscular disorders, muscular dystrophy, cystic fibrosis and genetic vaccination. This book should be of interest to clinicians, clinical researchers and basic scientists interested in the development of genetic therapies.

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9789401042420: Molecular and Cell Biology of Human Gene Therapeutics (Basic Life Sciences) (Molecular and Cell Biology of Human Diseases Series)

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Book Description Chapman and Hall, United Kingdom, 1995. Hardback. Condition: New. 1995 ed.. Language: English . This book usually ship within 10-15 business days and we will endeavor to dispatch orders quicker than this where possible. Brand New Book. advanced metastatic disease of solid tumors, dictates that each tumor mass, indeed each individual metastasis, will have a unique antigen and cytokine environment and hence unique response to immune modu- lation. A differential response to immunotherapy is thus inevitable. 4. Many of the human trials described are not randomized and report survival or response against historical controls. Most tumors described are immunogenic human tumors: renal cell cancer and melanoma are most common. In order to avoid the well-described inter-patient vari- ation and rare incidence of spontaneous response among patient samples as well as selection bias and changes in practice over time, randomized trials are required. 5. Immunological treatment is unlike conventional chemotherapy in its endpoint. Most chemotherapeutic regimes require a complete response or a good partial response for cure or good palliation. There are now many cases where immunotherapy has provided long-term palliation without massive tumor reduction. Immunity may be stimulated to a degree which holds tumorigenicity in check and most importantly, pro- vides good palliation for the patient in a manner that differs essentially from chemotherapy. Seller Inventory # LIE9780412625503

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Book Description Chapman and Hall, United Kingdom, 1995. Hardback. Condition: New. 1995 ed.. Language: English . Brand New Book ***** Print on Demand *****.advanced metastatic disease of solid tumors, dictates that each tumor mass, indeed each individual metastasis, will have a unique antigen and cytokine environment and hence unique response to immune modu- lation. A differential response to immunotherapy is thus inevitable. 4. Many of the human trials described are not randomized and report survival or response against historical controls. Most tumors described are immunogenic human tumors: renal cell cancer and melanoma are most common. In order to avoid the well-described inter-patient vari- ation and rare incidence of spontaneous response among patient samples as well as selection bias and changes in practice over time, randomized trials are required. 5. Immunological treatment is unlike conventional chemotherapy in its endpoint. Most chemotherapeutic regimes require a complete response or a good partial response for cure or good palliation. There are now many cases where immunotherapy has provided long-term palliation without massive tumor reduction. Immunity may be stimulated to a degree which holds tumorigenicity in check and most importantly, pro- vides good palliation for the patient in a manner that differs essentially from chemotherapy. Seller Inventory # APC9780412625503

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Book Description Chapman and Hall, United Kingdom, 1995. Hardback. Condition: New. 1995 ed.. Language: English . Brand New Book ***** Print on Demand *****. advanced metastatic disease of solid tumors, dictates that each tumor mass, indeed each individual metastasis, will have a unique antigen and cytokine environment and hence unique response to immune modu- lation. A differential response to immunotherapy is thus inevitable. 4. Many of the human trials described are not randomized and report survival or response against historical controls. Most tumors described are immunogenic human tumors: renal cell cancer and melanoma are most common. In order to avoid the well-described inter-patient vari- ation and rare incidence of spontaneous response among patient samples as well as selection bias and changes in practice over time, randomized trials are required. 5. Immunological treatment is unlike conventional chemotherapy in its endpoint. Most chemotherapeutic regimes require a complete response or a good partial response for cure or good palliation. There are now many cases where immunotherapy has provided long-term palliation without massive tumor reduction. Immunity may be stimulated to a degree which holds tumorigenicity in check and most importantly, pro- vides good palliation for the patient in a manner that differs essentially from chemotherapy. Seller Inventory # APC9780412625503

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