Neurologic Channelopathies (Volume 203) (Handbook of Clinical Neurology, Volume 203) - Hardcover

Hardcover

ISBN 10: 0323908209 ISBN 13: 9780323908207

Publisher: Elsevier, 2024

Synopsis

Neurological Channelopathies, Volume 203 begins with an introductory overview highlighting common mechanistic themes that cut across different CNS and PNS presentations, but that also have potential for common treatment approaches, considering classification, genetics, and fundamental physiology of ion channels. Subsequent chapters present a detailed consideration of all genetic and immunological channelopathies. Each chapter considers Pathophysiological underpinnings - genetic or immunological; Clinical presentations; Diagnostic approach; and Treatment and management.

In the last 15 years, a combination of detailed clinical, genetic, molecular electrophysiological, and immunological research has combined to result in a deep understanding of a subgroup of neurological diseases spanning the central and peripheral nervous system and which have become known collectively as the Neurological Channelopathies. Although it was originally considered that significant ion channel dysfunction would not be compatible with life, we now know this is often not the case, although severe disease can often be the result. Given these major advances, it is now the right time to combine this knowledge into a single HCN volume dedicated to the topics at hand.

• Identifies importance of ion channels to CNS & PNS function
• Considers the classification, genetics, and physiology of ion channels
• Presents all major immunological and genetic channelopathies
• Provides clinical presentation, diagnosis, and treatment of channelopathies

About this title

About the Author

Michael G Hanna is Director of the UCL Institute of Neurology, University College London and professor in clinical neurology and consultant neurologist at the National Hospital for Neurology and Neurosurgery, Queen Square, London, and also Director of the Medical Research Council (MRC) Centre for Neuromuscular Disease. He has published over 100 peer-reviewed papers in neurology, authored 15 book chapters and one book in clinical neurology. He serves as editor of the journal of Neurology, Neurosurgery, and Psychiatry.and is co-author of the textbook Tutorials in Differential Diagnosis, 4e.

From the Back Cover

In the last 15 years, a combination of detailed clinical, genetic, molecular electrophysiologic and immunologic research has combined to result in a deep understanding of a subgroup of neurologic diseases spanning the central and peripheral nervous system and which have become known collectively as the Neurologic Channelopathies. Ion channels are critical membrane bound proteins that underpin many fundamental processes in the central and peripheral nervous system including action potential generation and propagation and the control of neurotransmitter release at all CNS synapses as well as at the neuromuscular junction. Ion channels are consequently essential for all motor actions, cognitive functions and sensory perceptions. Although it was originally considered that significant ion channel dysfunction would not be compatible with life, we now know this is often not the case, although severe disease can often be the result. Given the fundamental processes that are dependent on ion channel function, it is perhaps unsurprising that genetic or immunologically mediated ion channel dysfunction can result in almost any neurologic symptom; patients may present to virtually any subspecialty within both adult and child neurology. The advances that have been made here have not only increased knowledge about the fundamental molecular mechanisms at play, but have also improved our ability to both diagnose and treat many of these disorders in clinical practice. Given these major advances, it is now the right time to combine this knowledge into a single HCN volume dedicated to the Neurologic Channelopathies. The book will begin with an introductory overview highlighting common mechanistic themes that cut across different CNS and PNS presentations but with potential for common treatment approaches. This initial chapter considers the classification, genetics, and fundamental physiology of ion channels. Subsequent chapters present a detailed consideration of all genetic and immunologic channelopathies. Each chapter will consider: Pathophysiologic underpinnings - genetic or immunologic; Clinical presentations; Diagnostic approach; Treatment and management.

Edition details

• Publisher: Elsevier
• Publication date: 2024
• Language: English
• ISBN 10: 0323908209
• ISBN 13: 9780323908207
• Binding: Hardcover
• Number of pages: 292
• Editor: Hanna Michael G.