Apoptosis: The molecular biology of programmed cell death: 40 (Frontiers in Molecular Biology) - Hardcover

Hardcover

ISBN 10: 0199638500 ISBN 13: 9780199638505

Publisher: OUP Oxford, 2002

Synopsis

Apoptosis is a regulated form of cell demise that can be induced or blocked by groups of specific stimuli. Occurring in all living tissues, it is thought critical to the maintenance of homeostasis and is implicated in lowering susceptibility to tumour growth. Conversely, over-sensitivity to apoptotic triggers can cause cells to be lost inappropriately from tissues, as appears to occur in neurodegenerative diseases.

This book examines the molecular pathways regulating apoptosis, progressing from the nematode worm through Drosphila to the more complex pathways evident in mammalian cells. Differences in the cell death pathway within specific tissues are addressed, as are the different genes that may act to regulate progressive steps.

About this title

Review

"[W]ell-written ... readable and thought provoking ... The editors each contribute excellent essays."--The Quarterly Review of Biology

About the Author

Michael Jacobson is at Millennium Pharmaceuticals Inc., Cambridge, MA, USA. Nicola McCarthy is at Division of Cardiovascular Medicine, Addenbrookes Hospital, Cambridge, UK.

Edition details

• Publisher: OUP Oxford
• Publication date: 2002
• Language: English
• ISBN 10: 0199638500
• ISBN 13: 9780199638505
• Binding: Hardcover
• Number of pages: 346
• Editor: Jacobson Michael, McCarthy Nicola