"The Polyketide Metabolite" provides a review of polyketide structure and biosynthesis. Polyketide metabolites (natural products biosynthesized largely by the condensation of acetate subunits) encompass a bewildering array of structures which can be grouped collectively by their common mode of construction. David O'Hagan examines the origin of different polyketides from various classes of organism, dealing with fatty acids, prostaglandins and related hormones, aromatic polyketides, and the more complex higher polyketides such as the macrolide and polyether antibiotics from bacteria and an ever increasing range of marine matabolites. Polyketides characteristic of bacteria, fungi, plants, insects, coral, sponges etc, are discussed - for example, the distribution of prostaglandins in various organisms including mammals, insects, plants and coral are reviewed, and structural correlations between metabolites (indicative of biogenetic relationships between producing organisms) are highlighted.Recent developments on the biosynthesis of the polyketide metabolites, which encompass both our understanding of the biochemistry and genetics of the polyketide producers, are dealt with throughout. The book will serve as an introductory text to those studying natural product chemistry and biosynthesis and will also be invaluable to researchers and specialists with a more general interest in natural products.
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