Chiral Separations by Hplc: Applications to Pharmaceutical Compounds (Ellis Horwood Series in Biochemistry and Biotechnology)

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9780131312364: Chiral Separations by Hplc: Applications to Pharmaceutical Compounds (Ellis Horwood Series in Biochemistry and Biotechnology)

Although much information exists on the differences in biological activities, potencies, toxicities, transport mechanisms and routes of metabolism off the enantiomers, the majority of pharmaceutical compounds containing an assymetric centre are still regarded as a racemic mixture. This volume dedicated to the application of chiral high performance liquid chromatography (HPLC) to stereo-chemistry in drug action, emphasizes the biochemical and analytical biochemical aspects. The editor has gathered together many international experts, incorporating contributions from the USA, Japan, Sweden, Poland, France, The Netherlands, and the UK. The first section reviews the origins of biomolecular chirality, reminding us of Pasteur's conception of dissymetry and its relevance to today's research findings, then proceeds to discuss the importance of the enantiomeric purity of drug substances and agrochemicals. The use of enzymes in stereospecific analyses is examined, as well as optical resolution by crystallization methods. Sections two and three focus on the use of HPLC in chiral separations, a technique currently experiencing a rise in popularity as a tool for the resolution of optically active compounds, as well as future developments. A final chapter presents a range of applications of HPLC chiral stationary phases.

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