Drugs and the Human Body: With Implications for Society

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9780130401724: Drugs and the Human Body: With Implications for Society

For undergraduate-level courses in Chemistry, Biology, Sociology and Criminal Justice. This text addresses the effects of high-use, high-abuse drugs in America in a timely, straightforward fashion. It reflects the most recent research on the most highly addictive drugs, including street, over-the-counter, and prescription drugs. It is designed to be easily accessible to the non-science major, yet comprehensive enough for use by the practicing professional.

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From the Publisher:

This book provides up-to-date information on high-use, high-abuse drugs in today's society. It is specifically designed to be easily accessible to non-science majors, yet comprehensive enough for use by practicing professionals. The Fifth Edition has been both updated and expanded to reflect the most recent research and the most relevant topics.

From the Inside Flap:

Preface

ATTENTION STUDENTS! This book is loaded with fascinating facts. To obtain the most from it, I urge you to make use of the following items:

More than 190 Web sites (URLs) are now included for your browsing. They have been selected for quality and pertinence to our coverage. Here are 3 super introductory sites you can browse right away: health(NationalClearinghouseforDrugInformation) usdoj.gov/dea/pubs/abuse/chapl/control/ analog. Htm (Drug Enforcement Administration) http: //drugs. ort. org/ cocaine. Htm (Photographs) Of course, you may also use your computer's search engines to locate hundreds of additional Internet sites. Drugs in Sports is a new chapter (Chapter 17) that presents up-to-date information on the use of drugs in sports competition. This topic has assumed major importance in America and around the world. Appendix II presents a 42-question self test on understanding alcoholism, with answers and comments offered by experts in the field. Keyword listings and learning objectives at the start of every chapter provide focus. In-chapter and end-of-chapter study questions will motivate you to examine and reexamine the chapters and learn the material. A glossary of more than 200 terms (Appendix IV) will help you master some of the language of pharmacology. Consult it often; it is a good learning tool by itself. For the chemistry-inclined, Appendix I gives organic chemical structures and structure-activity relationships for 14 categories of pharmacologically active compounds. DAWN Data summaries, found throughout the text and in Appendix 111, show us what drugs are causing problems, where in America, and to whom. More than two dozen true case histories present real-life examples of drug abuse Inside front and rear covers summarize drug trafficking in the United States and driving-under-the-influence facts.

TO THE PROFESSOR: This edition features a number of enhancements and updates.

A new chapter (Chapter 17) is devoted solely to the contentious topic of drugs in sports. Improved focus on issues related to women's health (Section 4.9). Coverage of drugs introduced since the last edition was published, including Ripped Fuel, retroviral inhibitors to treat AIDS, benzodiazepine tranquilizers, and designer estrogens. New figures and contemporary photos have been added. Recognizing the importance of the Internet, we now include web site listings in each chapter. New, real-life case studies have been added. Throughout the text, many other topics have been revised or updated, including withdrawal symptoms, molecular mechanisms involved in addiction and tolerance, behavioral pattern reinforcement, how to locate drug-abuse-oriented associations (via Web site, electronic mail, and telephone), generic drugs, Type 2 diabetes treatment, pregnancy tests, combinatorial chemistry, the Duract debacle, routes of drug administration, drugs in pregnancy, mechanisms of tolerance, introduction to the synapse, serotonin, heroin street price, mechanism of action of opiates, morphine pharmacology, endogenous opioids, methadone maintenance, numbers of U.S. cocaine/crack users, effects of passive smoking, smoking tobacco, DAWN data generally, drinking and driving, familial alcoholism, photosensitizers, marijuana, beta-phenethylamines, huffing, drug abuse treatments, NSAIDs, four classes of OTC drugs, drug testing, and others.

This book can be used in general health and drug education classes, counselor training, parent groups, and allied health fields in general-nursing, dental hygiene, medical technology, physical therapy, occupational therapy, medical records, and industrial hygiene.

As before, most drugs have been selected for inclusion on the basis of their high potential for abuse and misuse or their dramatic effect upon contemporary North American society. I discuss prescription drugs, over-thecounter drugs, street drugs, and recreational drugs.

This book provides facts about drug sources, history, action in the body, side effects, interactions, tolerance, abuse potential, dosage, dependency, drug delivery systems, and alternatives to drugs in use today. Students appear eager to discuss the impact of drugs on their lives, and this book provides a host of golden opportunities. Consider drug dependence (Chapter 1); quackery (Chapter 3); drugs and sex (Chapter 4); pain killers (Chapter 6); cocaine and amphetamines (Chapter 7); the fetal alcohol syndrome and lowering the drinking age (Chapter 9); drugs and stress (Chapter 5); what marijuana does to the body (Chapter 11); the resurgence of LSD and look-alike drugs (Chapter 12); oral contraceptives for men (Chapter 13); personal drug testing (Chapter 16); and drugs in sports (Chapter 17).

I have furnished brief histories of a number of topics, including the development of insulin, the discovery of the ergot alkaloids, and the use of LSD in America. I believe that the history of drugs is fascinating—and, as in the case of cancer quackery and the origin of the food, drug, and cosmetic laws—often highly instructive and personally useful.

Chapters 1-5 address definitions, concepts, theories, laws, and procedures that can be applied generally to many drug categories, For example, in Chapter 4, 1 discuss how drugs are administered, how they are distributed throughout the body, and what eventually happens to them. In this chapter, the concepts of drug life, drug metabolism, and interactions help explain how drug action can persist in the body and how drugs can have unexpected actions.

Assuming that the reader has little or no background in science, I have used few chemical formulas. For the student who has the necessary background, however, Appendix I provides a challenging study of structure-activity relationships of fourteen pharmacological classes of drugs. A glossary is provided in Appendix IV for those who are concerned about nomenclature.

Reader involvement in the text is encouraged by in-text problems and end-of-chapter questions and by means of a 42-question self-test on alcoholism (with answers and discussion in Appendix 11). Also, in Chapter 1, students are given the chance to establish a beginning vocabulary of physiology terms and to become familiar with the metric system.

For the instructor, a separate Instructor's Manual is available. It includes an introduction to each chapter, answers to all end-of-chapter questions, and a 725-question testbank, and can be ordered from your Prentice Hall representative (ISBN 0-13-085196-5).

Acknowledgments

I gratefully acknowledge the many valuable suggestions made by the reviewers of the fifth edition: Edward Bilsky, University of Northern Colorado; Thomas D. Kim, Youngstown State University; Frank R. Milio, Towson State University; Ruth Ann Murphy, University of Mary Hardin Baylor; Peter Norris, Youngstown State University. My thanks to Mr. John Challice, Chemistry Editor at Prentice Hall, and to Amanda Griffith, Chemistry Editorial Assistant at Prentice Hall, for encouragement and inspiration.

I hope you find this book useful and informative. I welcome any feedback or suggestions.

Ken Liska

pliska@ixcom

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