Bursting Neurons and Fading Memories: An Alternative Hypothesis of the Pathogenesis of Alzheimer's Disease - Softcover

D'Andrea, Michael R.

9780128019795: Bursting Neurons and Fading Memories: An Alternative Hypothesis of the Pathogenesis of Alzheimer's Disease

Softcover

ISBN 10: 0128019794 ISBN 13: 9780128019795

Publisher: Academic Press, 2014

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Bursting Neurons and Fading Memories

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Review:

"In addition to presenting and supporting his specific hypothesis, the author succeeds in conveying a number of important points regarding scientific research in general and the IHC methods specifically.... The methodical approach described here, including the careful attention to possible sources of artifacts, is a realistic portrayal of the hard work required both in the laboratory and at the microscope." -- Dr. Rhein Parri, Senior Lecturer in Pharmacology, School of Life and Health Sciences, Aston University, Birmingham, UK, in Biotechnic and Histochemistry

"....This book will delight the scientifically savvy reader with a guided tour of the process.... Dr. D’Andrea chronicles the process of scientific discovery in an insightful way that takes the reader on a journey... If you wanted a window into Alzheimer’s brain, here it is..... As a neuroscientist in the field, I found this book to be incredibly informative to the way I think about Alzheimer’s pathogenesis." - Holly Brothers, Postdoctoral Fellow, The Ohio State University, Columbus, OH, USA on Amazon

"Bursting Neurons and Fading Memories by Dr. Michael D’Andrea is a good book to read for those interested in Alzheimer’s disease (AD), its past research failures and its future promises.... The book provides valuable and specific staining techniques, some of which Dr. D’Andrea has devised through trial and error, that remind me of Ramὁn y Cajal’s early trials with improving silver nitrate stains at the turn of the 20th century, to gather details about the neuron’s structure and to discover some novel facts about how it dies in the damaged nervous system. I highly recommend this book." - Jack de la Torre, MD, PhD, Professor of Neuropsychiatry (Adjunct), Department of Psychology, University of Texas at Austin, Austin, TX, USA

"....Anyone wishing a clear description of the essential findings and the resulting hypothesis without having to consult the primary research papers will find their wish fully granted here. The writing is clear, the editing careful, and the references sufficient to show the way to the most relevant literature...." - Keith A. Crutcher, PhD, Neuroscientist, in the Journal of Alzheimer's Disease

About the Author:

Michael R. D'Andrea received his PhD in Cell and Developmental Biology and his MS in Molecular Biology at Rutger's University, New Brunswick, NJ, and his BA in Psycho-Biology at Western Maryland College, Westminster, MD. His dissertation work utilized molecular and histological assays to study the regulation of DNA topoisomerases in human cancers. His earlier career concerned the use of the high magnification electron microscopy to support oncogenesis in preclinical models, and then moved into a new field where he and his peers co-invented the chorionic villus sampling method at Thomas Jefferson for clinical chromosomal analysis. In the late 1980s and early 1990s, he mastered immunohistochemical methods at the light and electron microscopy levels when he began publishing his work in scientific journals. However, it wasn't until the mid-1990s, while working at Johnson & Johnson's Pharmaceutical Research & Development as the Target Validation Team Leader, did he become engaged in Alzheimer's disease (AD) research. His Team was responsible for supporting target discovery and validation, while supporting biomarker discovery in preclinical and experimental models using genomic, proteomic, and histopathological methods across many therapeutic areas and was honored with over a dozen Leadership and Scientific awards. Currently, he has over 100 scientifically peer-reviewed scientific publications and invited reviews, about a third of which concern the neuropathology of AD, and holds 11 scientific patents. He has reviewed hundreds of papers for many scientific journals, reviewed international grants in the AD field, and is currently on the editorial board of the journal, Biotechnic & Histochemistry. He has been invited to speak at numerous International, National, and Regional meetings, as well as at Universities and other companies to discuss his novel observations concerning the origin of amyloid plaques, the existence of v

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