Epigenetic Cancer Therapy (Translational Epigenetics) - Hardcover

9780128002063: Epigenetic Cancer Therapy (Translational Epigenetics)

Hardcover

ISBN 10: 0128002069 ISBN 13: 9780128002063

Publisher: Academic Press, 2015

Epigenetic Cancer Therapy unites issues central to a translational audience actively seeking to understand the topic. It is ideal for cancer specialists, including oncologists and clinicians, but also provides valuable information for researchers, academics, students, governments, and decision-makers in the healthcare sector.

The text covers the basic background of the epigenome, aberrant epigenetics, and its potential as a target for cancer therapy, and includes individual chapters on the state of epigenome knowledge in specific cancers (including lung, breast, prostate, liver).

The book encompasses both large-scale intergovernmental initiatives as well as recent findings across cancer stem cells, rational drug design, clinical trials, and chemopreventative strategies. As a whole, the work articulates and raises the profile of epigenetics as a therapeutic option in the future management of cancer.

Concisely summarizes the therapeutic implications of recent, large-scale epigenome studies, including the cancer epigenome atlas
Discusses targeted isoform specific versus pan-specific inhibitors, a rational drug design approach to epigenetics relevant to pharmacoepigenetic clinical applications
Covers new findings in the interplay between cancer stem cells (CSCs) and drug resistance, demonstrating that epigenetic machinery is a candidate target for the eradication of these CSCs

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Review:

"...a helpful reference for researchers and medical professionals interested in epigenetics...contains many resources that may be useful for readers or guide them to technologies and areas of interest quickly. Score: 84 - 3 Stars" --Doody's

Review:

An ideal companion for translational researchers and clinicians conducting R&D, and for those considering incorporating epigenetic targeting agents into clinical trial protocols

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