Capsaicin in the Study of Pain (Neuroscience Perspectives)

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9780127628554: Capsaicin in the Study of Pain (Neuroscience Perspectives)

The neurosciences are one of the most diverse and rapidly changing areas in the biological sphere. The need to understand the workings of the nervous system pervades a vast array of different research areas. By definition research in the neurosciences encompasses anatomy, pathology, biochemistry, physiology, pharmacology, molecular biology, genetics, and therapeutics. The ultimate goal is to determine how the human brain functions under normal circumstances and perhaps, more importantly, how function changes in organic disease and in altered states of mind. The key to many of these illnesses will unlock one of the major therapeutic challenges of this era.
The difficulty lies in the vastness of the subject matter. The whole idea behind Neuroscience Perspectives is to provide a series of individual edited monographs which deal in depth with issues of current interest to those working in the neuroscience area. Each volume is designed to bring a multidisciplinary approach to the subject matter by pursuing the topic from the laboratory to the clinic. The editors of the individual volumes are producing balanced critiques of each topic to provide the reader with an up-to-date, clear, comprehensive view of the state of the art.

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Neuroscience Perspectives provides multidisciplinary reviews of topics in one of the most diverse and rapidly advancing fields in the life sciences.
Whether you are a new recruit to neuroscience, or an established expert, look to this series for 'one-stop' sources of the historical, physiological, pharmacological, biochemical, molecular biological and therapeutic aspects of chosen research areas.
Capsaicin is the pungent ingredient of red peppers of the capsicum family. It has been found to activate a sub-population of sensory neurones, and to evoke a sensation of burning pain. Capsaicin has attracted much attention as a tool to study the function of sensory neurones. Not only does capsaicin activate subsets of sensory neurones, but high doses of capsaicin also kill them, allowing their functional role to be defined.
As well as evoking a sensation of pain, capsaicin can, paradoxically, have analgesic and anti-inflammatory effects. This observation has inspired attempts to develop novel analgesic drugs based on the selective action of capsaicin on neurones that respond to tissue-damaging stimuli.
This volume provides an overview of recent progress in understanding the mechanism and site of action of capsaicin. A major recent advance has been the identification of an ultrapotent capsaicin analogue, resiniferatoxin, which has provided an invaluable biochemical tool for the characterization of capsaicin receptors. The use of capsaicin to define the efferent function of peptidergic sensory neurones is reviewed, and the significance of capsaicin in the study of pain and the recent development of novel analgesic and anti-inflammatory drugs based on the structure of capsaicin is discussed.
This book provides a complete introduction to an area of sensory neurobiology of both fundamental and clinical importance, written by researchers who have contributed to the recent rapid progress in capsaicin research.

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John N. Wood (Editor), Peter Jenner (Series Editor)
Published by Academic Press (1993)
ISBN 10: 012762855X ISBN 13: 9780127628554
New Hardcover Quantity Available: 1

Book Description Academic Press, 1993. Hardcover. Book Condition: New. Bookseller Inventory # DADAX012762855X

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