The Kidney: From Normal Development to Congenital Disease - Hardcover

Hardcover

ISBN 10: 0127224416 ISBN 13: 9780127224411

Publisher: Academic Press, 2003

Synopsis

Organogenesis of the kidney has been intensely studied for over a century. In recent years advances in molecular techniques have not only made great inroads into exploring the genetic regulation of this complex process but also began to unravel the molecular basis of many forms of congenital kidney disease. This book is a comprehensive study on these findings and the only book available with such in depth coverage of the kidney.

• Hundreds of color figures depicting key events in all aspects of kidney development
• Full coverage of the genetic and cellular basis of kidney development
• Analysis of the genetic basis of the major congenital kidney diseases

About this title

Review:

"It is well written and will be useful both for students and researchers in developmental biology, as well as clinical nephrologists and urologists. This book clearly outlines the development of the human kidney from an evolutionary perspective. In addition, it describes the pronephros and the mesonephros in great detail...The book concludes with an excellent review of therapies for congenital kidney diseases, including gene-transfer techniques and cell-based therapies. Overall, The Kidney is well organized and well written...an excellent resource for the researcher in kidney development and developmental diseases, and an outstanding reference for clinical pediatric nephrologists and urologists." --TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2004

"finding this book was like driving to the top of a small hill only to find a magnificent, snow-capped mountain range rising a dozen or so miles ahead, begging to be explored. ...an excellent point of departure for laboratory trainees, as well as more senior scientists, who may want to catch up on the fundamentals of renal development in the modern era without much of a struggle." --AMERICAN JOURNAL OF KIDNEY DISEASES, August 2003

"The book is well organized, lucidly written, and superbly illustrated. ...does a fine job of emphasizing that the kidney is a wonderful system in which to study many critical issues in cellular and developmental biology."  --THE NEW ENGLAND JOURNAL OF MEDICINE, November 2003

"Recommended for medical and academic libraries and renal specialists."  --E-STREAMS, September 2003

"This reader appreciates the imaginative handling of the illustrations that deal with pronephic, mesonephric, and metanephric development in a way that complements the excellent text descriptions...this book is an excellent point of departure for labratory trainees, as well as more senior scientists, like me, who may want to catch up on the fundamentals of renal development in the modenrn era without much of a struggle" -KIDNEY INSTITUTE, UNIVERSITY OF KANSAS MEDICAL CENTER, 2003

From the Back Cover:

Organogenesis of the kidney has been intensely studied for over a century. In recent years advances in molecular techniques have not only made great inroads in exploring the genetic regulation of this complex process but have also begun to unravel the molecular basis of many forms of congenital kidney disease. The Kidney is divided into three major sections covering specific subject areas. The first presents invertebrate and embryonic kidneys as powerful new approaches to investigating the molecular regulation of specification, morphogenesis, organogenesis and physiology of the kidney. Section 2 describes the anatomy, development and physiology of the adult kidney, the metanephros in extraordinary detail. Separate chapters explore each stage and component of metanephric organogenesis from the first inductive interactions up until the acquisition of function. The final section explores our current knowledge of the molecular basis of congenital kidney disorders and the abnormal development programs that result in kidney disease.

Key Features
* Hundreds of color figures depicting key events in all aspects of kidney development
* Full coverage of the genetic and cellular basis of kidney development
* Model systems for embryologic and genetic investigations of organogenesis (chick, Drosophila, mouse, Xenopus, zebrafish)
* Molecular and developmental basis of kidney function
* Detailed methods and techniques that make the kidney a uniquely powerful experimental system
* Analysis of the genetic basis of the major congenital kidney diseases|Organogenesis of the kidney has been intensely studied for over a century. In recent years advances in molecular techniques have not only made great inroads in exploring the genetic regulation of this complex process but have also begun to unravel the molecular basis of many forms of congenital kidney disease. The Kidney is divided into three major sections covering specific subject areas. The first presents invertebrate and embryonic kidneys as powerful new approaches to investigating the molecular regulation of specification, morphogenesis, organogenesis and physiology of the kidney. Section 2 describes the anatomy, development and physiology of the adult kidney, the metanephros in extraordinary detail. Separate chapters explore each stage and component of metanephric organogenesis from the first inductive interactions up until the acquisition of function. The final section explores our current knowledge of the molecular basis of congenital kidney disorders and the abnormal development programs that result in kidney disease.

Key Features
* Hundreds of color figures depicting key events in all aspects of kidney development
* Full coverage of the genetic and cellular basis of kidney development
* Model systems for embryologic and genetic investigations of organogenesis (chick,Drosophila, mouse, Xenopus, zebrafish)
* Molecular and developmental basis of kidney function
* Detailed methods and techniques that make the kidney a uniquely powerful experimental system
* Analysis of the genetic basis of the major congenital kidney diseases

About this edition

• Publisher: Academic Press
• Publication date: 2003
• ISBN 10: 0127224416
• ISBN 13: 9780127224411
• Binding: Hardcover
• Number of pages: 592
• Editor: Vize Peter D., Woolf Adrian S., Bard Jonathan B.L.