Biochemistry of Redox Reactions (Metabolism of Drugs and Other Xenobiotics)

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9780126853919: Biochemistry of Redox Reactions (Metabolism of Drugs and Other Xenobiotics)

Surpassing the 1976 book by Testa and Jenner, Drug Metabolism: Chemical and Biochemical Aspects (Dekker), this informative, up-to-date text includes the following features, unavailable elsewhere: First in a set of books to provide a comprehensive coverage of drug metabolism; Opening chapter provides a general introduction to the complete set of books; Other chapters cover reaction mechanisms, catalytic cycles, regio- and stereoselectivities, types of substrates, reactivity of intermediates, and drug-enzyme interactions; Extensive detailed diagrams of reaction pathways and chemical structures

* First in a set of books providing a comprehensive coverage of drug metabolism

* Opening chapter provides a general introduction to the complete set of books

* Other chapters cover reaction mechanisms, catalytic cycles, regio and stereoselectivities, types of substrates, reactivity of intermediates and drug-enzyme interactions

* Extensive detailed diagrams of reaction pathways and chemical structures

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From the Back Cover:

In the present volume, the first in the Series The Metabolism of Drugs and Other Xenobiotics, Professor Testa discusses the molecular and biochemical aspects of reactions of oxidation and reduction. While an encyclopaedic treatment is avoided, the covered topics include biochemical properties of the enzymes/isoenzymes, drug-enzyme interactions, the various chemical reactions catalyzed by the enzyme (s), reaction mechanisms and catalytic cycles, regio- and stereoselectivities, structure-metabolism relationships, the reactivity of metabolic intermediates and molecular aspects of toxication and detoxication, as well as molecular mechanisms of direct and indirect enzyme inhibition. The classification of matters is based firstly on enzymes and their reactions, and secondly on the types of target groups being transformed, with carefully selected examples illustrating the reactions under discussion. Such a treatment has heuristic value since it renders the reader capable of educated guesses on the metabolism of other or novel drugs. Forthcoming volumes in the Series will present reactions of hydration and conjugation, and the biological regulations and consequences of xenobiotic metabolism.

About the Author:

John Caldwell lives in Scotland and is a bi-vocational ministry assistant who works for the Free Church of Scotland and also teaches in a local high school. Prior to entering the teaching profession he worked for Paisley YMCA in a number of projects that reached out to young people throughout Renfrewshire.

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Bernard Testa (Editor), John Caldwell (Editor)
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Book Description Elsevier Science Publishing Co Inc, United States, 1994. Hardback. Book Condition: New. Language: English . Brand New Book. Surpassing the 1976 book by Testa and Jenner, Drug Metabolism: Chemical and Biochemical Aspects (Dekker), this informative, up-to-date text includes the following features, unavailable elsewhere: First in a set of books to provide a comprehensive coverage of drug metabolism; Opening chapter provides a general introduction to the complete set of books; Other chapters cover reaction mechanisms, catalytic cycles, regio- and stereoselectivities, types of substrates, reactivity of intermediates, and drug-enzyme interactions; Extensive detailed diagrams of reaction pathways and chemical structures. Bookseller Inventory # AA59780126853919

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Published by Elsevier Science Publishing Co Inc, United States (1994)
ISBN 10: 0126853916 ISBN 13: 9780126853919
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Book Description Elsevier Science Publishing Co Inc, United States, 1994. Hardback. Book Condition: New. Language: English . Brand New Book. Surpassing the 1976 book by Testa and Jenner, Drug Metabolism: Chemical and Biochemical Aspects (Dekker), this informative, up-to-date text includes the following features, unavailable elsewhere: it is first in a set of books to provide a comprehensive coverage of drug metabolism; the opening chapter provides a general introduction to the complete set of books; other chapters cover reaction mechanisms, catalytic cycles, regio- and stereoselectivities, types of substrates, reactivity of intermediates, and drug-enzyme interactions; it includes extensive detailed diagrams of reaction pathways and chemical structures. First in a set of books providing a comprehensive coverage of drug metabolism, its opening chapter provides a general introduction to the complete set of books. Other chapters cover reaction mechanisms, catalytic cycles, regio and stereoselectivities, types of substrates, reactivity of intermediates and drug-enzyme interactions. It includes extensive detailed diagrams of reaction pathways and chemical structures. Bookseller Inventory # AA59780126853919

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