DNA Methylation and Complex Human Disease (Translational Epigenetics) - Hardcover

Neidhart, Michel

Hardcover

ISBN 10: 0124201946 ISBN 13: 9780124201941

Publisher: Academic Press, 2015

Synopsis

DNA Methylation and Complex Human Disease reviews the possibilities of methyl-group-based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future uses of high-throughput methylome technologies. This volume includes many pertinent advances in disease-bearing research, including obesity, type II diabetes, schizophrenia, and autoimmunity. DNA methylation is also discussed as a plasma and serum test for non-invasive screening, diagnostic and prognostic tests, as compared to biopsy-driven gene expression analysis, factors which have led to the use of DNA methylation as a potential tool for determining cancer risk, and diagnosis between benign and malignant disease. Therapies are at the heart of this volume and the possibilities of DNA demethylation. In cancer, unlike genetic mutations, DNA methylation and histone modifications are reversible and thus have shown great potential in the race for effective treatments. In addition, the authors present the importance of high-throughput methylome analysis, not only in cancer, but also in non-neoplastic diseases such as rheumatoid arthritis. * Discusses breaking biomarker research in major disease families of current health concern and research interest, including obesity, type II diabetes, schizophrenia, and autoimmunity* Summarizes advances not only relevant to cancer, but also in non-neoplastic disease, currently an emerging field* Describes wholly new concepts, including the linking of metabolic pathways with epigenetics* Provides translational researchers with the knowledge of both basic research and clinic applications of DNA methylation in human diseases

About this title

Review:

This book describes the modifications of DNA methylation in various major human disease groups, including nonneoplastic diseases that could provide a rationale to develop novel therapeutic strategies such as the use of DNA methylation as a potential tool for determining cancer risk.

From the Back Cover:

In DNA Methylation in Complex Human Disease, expert authors review the possibilities of methyl-group-based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future uses of high-throughput methylome technologies. This volume includes many pertinent advances in disease-bearing research, including therapies and the possibility of using methyl donors. DNA methylation is also discussed as a plasma and serum test for non-invasive screening, diagnostic and prognostic tests, as compared to biopsy-driven gene expression analysis. The authors also present the importance of high-throughput methylome analysis, as well as the advantages of DNA methylation as a biomarker over other molecular processes. DNA Methylation in Complex Human Disease is an excellent resource for basic biology and translational researchers interested in developmental biology, genetics health genomics, epigenesist in complex disease, and therapeutic possibilities, and developmental biologists, geneticists, biotechnologists, and epidemiologists have much to gain from this specialized and focused volume.

About this edition

• Publisher: Academic Press
• Publication date: 2015
• ISBN 10: 0124201946
• ISBN 13: 9780124201941
• Binding: Hardcover
• Number of pages: 552