This book is the first definitive overview on adenosine receptor antagonists and their application to the treatment of Parkinson's Disease. The effect of these novel non-dopamine drugs on vitro and in vivo systems clearly shows their potential for the treatment of this debilitating disease. This book covers how the Parkinson's disease antagonist drug, A2A, has been researched, developed, and tested. It is an essential book for researchers interested in the basal ganglia, purine biology, and Parkinson's Disease.
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The book is the first and, at present time, the only definitive overview on adenosine antagonists and Parkinson's disease. Coverage includes groundbreaking research on biochemistry, molecular biology, medicinal chemistry, electrophysiology, pharmacology, and neurochemistry to delineate a novel mechanism and concept of adenosine A2A receptor antagonists for the therapeutic approach to Parkinson's disease.About the Author:
Hiroshi Kase, Kyowa Hakko Kogyo Co., Ltd., Tokyo, Japan
Peter J. Richardson, University of Cambridge, U.K.
Peter Jenner, King's College London, U.K.
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