Items related to Translational Neuroimaging: Tools for CNS Drug Discovery,...

Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment - Hardcover

 
9780123869456: Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment
View all copies of this ISBN edition:
 
 

Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment combines the experience of academic, clinical and industrial neuroimagers in a unique collaborative approach to provide an integrated perspective of the use of small animal and human brain imaging in developing and validating translational models and biomarkers for the study and treatment of neuropsychiatric disorders. Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment examines the translational role of neuroimaging in model development from preclinical animal models, to human experimental medicine, and finally to clinical studies. The focus of this book is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery. This book covers methodical issues in human and animal neuroimaging translational research as well as detailed applied examples of the use of neuroimaging in neuropsychiatric disorders and the development of drugs for their treatment. Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment appeals to non-clinical and clinical neuroscientists working in and studying neuropsychiatric disorders and their treatment as well as providing the novice researcher or researcher outside of his/her expertise the opportunity to understand the background of translational research and the use of imaging in this field.



  • Provides a background to translational research and the use of brain imaging in neuropsychiatric disorders
  • Critical discussion of the potential and limitations of neuroimaging as a translational tool for identifying and validating biomarkers
  • Identifies cross species neurosystems and common endpoints necessary to help accelerate CNS drug discovery and development for the treatment of neuropsychiatric disorders

"synopsis" may belong to another edition of this title.

Review:

"This book examines how neuroimaging can play a role in translational research by developing preclinical models and ultimately clinical studies for drug discovery."--Doody.com, October 17, 2013 "Researchers in imaging technology, neurology, and mental health sciences introduce fundamental concepts of neuroimaging, the various modalities being used, how it is being used to study central nervous system (CNS) disorders, and specifically how it is being used to discover and develop drugs for such disorders."--Reference & Research Book News, October 2013

About the Author:

Dr. McArthur began his professional career investigating the role of serotonin on feeding behaviour at the Clarke Institute of Psychiatry in Toronto, Canada. This interest led him to complete a PhD in the psychopharmacology of feeding behaviour and macronutrient selection with John Blundell at the University of Leeds, Leeds, UK.

In 1981 he joined Beecham Pharmaceuticals to work on adrenergic involvement in energy expenditure and obesity. In 1983 Dr McArthur began working on M1 functional agonists for the treatment of Alzheimer disease and was responsible for demonstrating the initial procognitive effects of Sabcomeline. Following the merger of Beecham with SmithKline French, Dr McArthur was appointed Business Development Executive at I.T.E.M-Labo, Paris working with Roger Porsolt in behavioural pharmacology contract research. In 1992, Robert was appointed Head of Behavioral Pharmacology at Farmitalia Carlo Erba, later Pharmacia in Milan. His lab was responsible for the preclinical behavioural pharmacology of Sabcomeline (Alzheimer’s and schizophrenia); Safinamide (epilepsy and Parkinson’s); Reboxetine (depression); Cabergoline (Parkinson’s); Nicergoline (Mild Cognitive Impairment); and Amperozide (alcoholism).

He is listed as an inventor in 19 issued patents and applications of which he is the principal inventor in 3. In 1998, Robert transferred to the Pharmacia and Upjohn Company in Kalamazoo, Michigan where as senior behavioural pharmacologist responsible, he worked on mutant mouse characterizations, the establishment of a primate unit assessing cognitive changes in monkeys (CANTAB), and development of anxiety models in marmosets. Soon after the merger of Pharmacia and Upjohn with Monsanto-Searle, Robert returned to Europe where in 2001 he founded the consulting company, McArthur and Associates GmbH in Basel.

Robert has since worked on a series of projects for both large Pharma as well as biotechs, including further primate work in Parkinson’s, development of behavioural pharmacology expertise, novel target validation, due diligence, medical writing, strategy evaluation, scientific advisor and as an expert witness. Dr McArthur has pursued his academic interests in translational neuroscience. In 2003, Robert was appointed as a visiting Associate Research Professor in the Department of Neuroscience (Division of Behavioural Neuroscience) at the Karolinska Institute in Stockholm.

He has written and co-edited extensively on the subject of the clinical and translational relevance of animal models of CNS disorders. He has authored 43 peer-reviewed papers, 13 book chapters, co-author on 1 book and senior editor of a three-volume set on translational value of animal models for CNS drug discovery. He has served as section editor (CNS) for Current Opinion in Investigational Drugs and is on the editorial board of Drugs of the Future. In 2009 he was appointed an independent scientific expert evaluator for the European FP7-Health call.

"About this title" may belong to another edition of this title.

  • PublisherAcademic Press
  • Publication date2012
  • ISBN 10 0123869455
  • ISBN 13 9780123869456
  • BindingHardcover
  • Number of pages448

Shipping: £ 14.99
From United Kingdom to U.S.A.

Destination, rates & speeds

Add to Basket

Top Search Results from the AbeBooks Marketplace

Stock Image

Robert McArthur
Published by Academic Press 2012-11-26 (2012)
ISBN 10: 0123869455 ISBN 13: 9780123869456
New Hardcover Quantity: > 20
Seller:
Chiron Media
(Wallingford, United Kingdom)

Book Description Hardcover. Condition: New. Seller Inventory # 6666-ELS-9780123869456

More information about this seller | Contact seller

Buy New
£ 108.69
Convert currency

Add to Basket

Shipping: £ 14.99
From United Kingdom to U.S.A.
Destination, rates & speeds
Stock Image

McArthur, Robert
Published by Lala Maurizio (2012)
ISBN 10: 0123869455 ISBN 13: 9780123869456
New Hardcover Quantity: > 20
Print on Demand
Seller:
Brook Bookstore On Demand
(Napoli, NA, Italy)

Book Description Condition: new. Questo è un articolo print on demand. Seller Inventory # 0211788ae02c5b8753f241ecd390a778

More information about this seller | Contact seller

Buy New
£ 126.40
Convert currency

Add to Basket

Shipping: £ 9.54
From Italy to U.S.A.
Destination, rates & speeds
Stock Image

Mcarthur, Robert A. (Editor)
Published by Academic Pr (2012)
ISBN 10: 0123869455 ISBN 13: 9780123869456
New Hardcover Quantity: 2
Seller:
Revaluation Books
(Exeter, United Kingdom)

Book Description Hardcover. Condition: Brand New. 1st edition. 421 pages. 10.00x8.00x1.00 inches. In Stock. Seller Inventory # __0123869455

More information about this seller | Contact seller

Buy New
£ 129.22
Convert currency

Add to Basket

Shipping: £ 10
From United Kingdom to U.S.A.
Destination, rates & speeds
Seller Image

Robert A. McArthur
Published by ACADEMIC PR INC (2012)
ISBN 10: 0123869455 ISBN 13: 9780123869456
New Hardcover Quantity: 1
Seller:
AHA-BUCH
(Einbeck, Germany)

Book Description Gebundene Ausgabe. Condition: Neu. Neu neuware, importqualität, auf lager - Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment combines the experience of academic, clinical and industrial neuroimagers in a unique collaborative approach to provide an integrated perspective of the use of small animal and human brain imaging in developing and validating translational models and biomarkers for the study and treatment of neuropsychiatric disorders. Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment examines the translational role of neuroimaging in model development from preclinical animal models, to human experimental medicine, and finally to clinical studies. The focus of this book is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery. This book covers methodical issues in human and animal neuroimaging translational research as well as detailed applied examples of the use of neuroimaging in neuropsychiatric disorders and the development of drugs for their treatment. Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment appeals to non-clinical and clinical neuroscientists working in and studying neuropsychiatric disorders and their treatment as well as providing the novice researcher or researcher outside of his/her expertise the opportunity to understand the background of translational research and the use of imaging in this field. Provides a background to translational research and the use of brain imaging in neuropsychiatric disorders Critical discussion of the potential and limitations of neuroimaging as a translational tool for identifying and validating biomarkers Identifies cross species neurosystems and common endpoints necessary to help accelerate CNS drug discovery and development for the treatment of neuropsychiatric disorders. Seller Inventory # INF1000416225

More information about this seller | Contact seller

Buy New
£ 195.17
Convert currency

Add to Basket

Shipping: £ 28.27
From Germany to U.S.A.
Destination, rates & speeds