Handbook of Pharmacogenomics and Stratified Medicine - Hardcover

Sandosh Padmanabhan

9780123868824: Handbook of Pharmacogenomics and Stratified Medicine

Hardcover

ISBN 10: 0123868823 ISBN 13: 9780123868824

Publisher: Academic Press, 2014

Handbook of Pharmacogenomics and Stratified Medicine is a comprehensive resource to understand this rapidly advancing field aiming to deliver the right drug at the right dose to the right patient at the right time. It is designed to provide a detailed, but accessible review of the entire field from basic principles to applications in various diseases. The chapters are written by international experts to allow readers from a wide variety of backgrounds, clinical and non-clinical (basic geneticists, pharmacologists, clinicians, trialists, industry personnel, ethicists) to understand the principles underpinning the progress in this area, the successes, failures and the challenges ahead. To be accessible to the widest range of readers, the clinical application section introduces the disease process, existing therapies, followed by pharmacogenomics and stratified medicine details.

Medicine is the cornerstone of modern therapeutics prescribed on the basis that its benefit should outweigh its risk. It is well known that people respond differently to medications and in many cases the risk-benefit ratio for a particular drug may be a gray area. The last decade has seen a revolution in genomics both in terms of technological innovation and discovering genetic markers associated with disease. In parallel there has been steady progress in trying to make medicines safer and tailored to the individual. This has occurred across the whole spectrum of medicine, some more than others. In addition there is burgeoning interest from the pharmaceutical industry to leverage pharmacogenomics for more effective and efficient clinical drug development.

Provides clinical and non-clinical researchers with practical information normally beyond their usual areas of research or expertise
Includes an basic principles section explaining concepts of basic genetics, genetic epidemiology, bioinformatics, pharmacokinetics and pharmacodynamics
Covers newer technologies- next generation sequencing, proteomics, metabolomics
Provides information on animal models, lymphoblastoid cell lines, stem cells
Provides detailed chapters on a wide range of disease conditions, implementation and regulatory issues
Includes chapters on the global implications of pharmacogenomics

"synopsis" may belong to another edition of this title.

Review:

"...a comprehensive resource to understand this rapidly advancing field aiming to deliver the right drug at the right dose to the right patient at the right time." --Anticancer Research, January 2015

"This is an extremely useful resource for clinicians, scientists, or any individuals interested in an excellent review of the rapidly advancing field of pharmacogenomics and its increasing relevance for clinical practice. - Rating: 5 Stars" --Doody's.com, Oct 2014

About the Author:

Dr Sandosh Padmanabhan is a Reader and Honorary Consultant Physician at the Institute of Cardiovascular and Medical Sciences, University of Glasgow. His research spans the genetics of cardiovascular traits, pharmacogenomics and stratified medicines and hypertension epidemiology.

"About this title" may belong to another edition of this title.