Nutrigenetics: Applying the Science of Personal Nutrition provides a fully referenced, readable guide to understanding the rationale and importance of nutrigenetic applications and explains why single nutrition recommendations will not fit everybody or even a majority of modern humans.
This books explains how genetic variation shapes individual nutrition requirements and sensitivities, presents questions to ask about reported gene-nutrient interactions, and what needs to be done before putting nutrigenetic tests to practical use. This book blends key concepts from the fields of genetics, biochemistry, epidemiology, public health, and clinical medicine to give a rich perspective on the genetically diverse nutritional needs and sensitivities of individuals in health and disease.
A steadily increasing number of people order genetic tests to find out what they should eat for better health, well being and performance, and an even greater number asks their healthcare providers about such tests. Most of the currently offered tests are not grounded in current knowledge, often absurdly so, but few professionals can explain why they are misguided. On the other hand, there are more evidence-supported genetic variants that can guide nutrition decisions, but again most healthcare providers know little about them, much less use them in their daily practice. There is a great need for a solidly evidence-based yet accessible book that explains the science of nutrigenetics and provides the tools to evaluate new nutrigenetic tests.
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Martin Kohlmeier, MD, PhD is professor at the University of North Carolina at Chapel Hill, is
Director of the Nutrition in Medicine project, and heads the Nutrigenetics laboratory at the UNC
Nutrition Research Institute. His nutrition research has focused on the importance of inherited
variation as a modulator of nutrient disposition and on the assessment of nutritional status of
normal populations and its impact on health. He identified low endogenous cholesterol synthesis
as a cause of increased cholesterol sensitivity, the apolipoprotein E polymorphism as the main
genetic modulator of vitamin K status, lactase persistence as a modulator of phytoestrogen
bioavailability, and a very common MTHFD1 variant as a predictor of choline requirements. He
has developed online tools that provide genotype-specific personalized nutrition guidance
without revealing genetic information.
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