Handbook of the Biology of Aging (Handbooks of Aging)

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9780123786388: Handbook of the Biology of Aging (Handbooks of Aging)

"The Handbook of the Biology of Aging, 7 edition", is 100 per cent revised from the 6th edition. Providing a comprehensive synthesis and review of the latest research findings in the biology of aging, it is intended as a summary for researchers, and is also suitable as a high level textbook for graduate and upper level undergraduate courses. The 7th edition is organized into two main sections, first covering the basic aging processes and then the medical physiology of aging. This puts less emphasis on research germane only to specific species and more emphasis on the mechanisms that affect aging across species, and what this means medically for the aging of humans. This volume allows basic researchers to keep abreast of basic research outside their subdiscipline as well as recent clinical findings, while allowing medical, behavioral, and social gerontologists to understand what basic scientists and clinicians are discovering. Coverage of basic aging processes includes the effects of dietary restriction, somatotropic axis, free radicals, apoptosis, adipose tissue, stem cells, leukocyte telomere dynamics, genetics, sirtuins, inflammation, and protein homeostasis on aging. Coverage of the medical physiology of aging includes several chapters on aging effects on the human brain including changes in brain myelination, cerebral microvasculature, and cerebral vascular dysfunction. Additional chapters include research on aging pulmonary function, insulin secretion, thermoreception and thermoregulation, calorie restriction, frailty & mortality, and sex differences in longevity and aging. This more clinically-oriented section advances our understanding of what to expect, how to prevent, and how to treat common medical effects of aging. "The Handbook of the Biology of Aging, 7 edition" is part of "The Handbooks of Aging series", including "Handbook of the Psychology of Aging" and "Handbook of Aging and the Social Sciences", also in their 7th editions. It contains basic aging processes as determined by animal research as well as medical physiology of aging as known in humans. It covers hot areas of research, like stem cells, integrated with longstanding areas of interest in aging like telomeres, mitochondrial function, etc. It is edited by one of the fathers of gerontology (Masoro) and contributors represent top scholars in gerintology.

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Product Description:

Handbook of the Biology of Aging, Seventh Edition, reviews and synthesizes recent findings and discoveries in the field. This volume is part of The Handbooks of Aging series, which also includes The Handbook of the Psychology of Aging and The Handbook of Aging and the Social Sciences. The book is organized into two parts. Part 1 covers basic aging processes. It covers concepts relevant to clinical research, such as muscle, adipose tissue, and stem cells. It discusses research on how dietary restriction can slow down the aging process and extend life in a wide range of species. Part 2 deals with the medical physiology of aging. It contains several chapters on the aging of the human brain. These chapters deal not only with diseases but also with normal aging changes to cerebral vasculature and myelination as well as the clinical implications of those changes. Additional chapters cover how aging affects central features of human health such as insulin secretion, pulmonary and cardiac function, and the ability to maintain body weight and body temperature. The volume is primarily directed at basic researchers who wish to keep abreast of new research outside their own subdiscipline. It will also be useful to medical, behavioral, and social gerontologists who want to learn about the discoveries of basic scientists and clinicians. * Contains basic aging processes as determined by animal research as well as medical physiology of aging as known in humans* Covers hot areas of research, like stem cells, integrated with longstanding areas of interest in aging like telomeres, mitochondrial function, etc.* Edited by one of the fathers of gerontology (Masoro) and contributors represent top scholars in gerintology

Review:

"This is an important and timely book on an extremely critical subject, and although its technical excellence and depth will challenge those without a formal background in molecular biology, the rewards I believe will be deeply commensurate with the effort. However, with that qualification in mind, the articles are uniformly of high quality and address critical issues in the science of aging-several, if not many, of these reviews are good enough to be considered benchmark reviews, cogently summarizing the state of the science. For those interested in a benchmark series of reviews on aging, this volume has much to offer. I recommend it highly. For geriatric neuropsychologists, sophistication about the biology of aging should be considered a required area of competence."--Archives of Clinical Neuropsychology

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Masoro, Edward J. / Austad, Steven N.
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