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Complex enzymes in microbial natural product biosynthesis, Part A: overview articles and peptides (Methods in Enzymology): Volume 458 - Hardcover

 
9780123745880: Complex enzymes in microbial natural product biosynthesis, Part A: overview articles and peptides (Methods in Enzymology): Volume 458
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This volume will showcase the most important chemical classes of peptides, which have been an important traditional source of valuable antibiotics and other drugs.

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  • PublisherAcademic Press
  • Publication date2009
  • ISBN 10 0123745888
  • ISBN 13 9780123745880
  • BindingHardcover
  • Edition number1
  • Number of pages350
  • EditorDavid A. Hopwood

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David A. Hopwood
Published by Academic Press 2009-06-01 (2009)
ISBN 10: 0123745888 ISBN 13: 9780123745880
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Hopwood, David A. (Editor)
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Published by ACADEMIC PR INC Apr 2009 (2009)
ISBN 10: 0123745888 ISBN 13: 9780123745880
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Book Description Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Microbial natural products have been an important traditional source of valuable antibiotics and other drugs but interest in them waned in the 1990s when big pharma decided that their discovery was no longer cost-effective and concentrated instead on synthetic chemistry as a source of novel compounds, often with disappointing results. Moreover understanding the biosynthesis of complex natural products was frustratingly difficult. With the development of molecular genetic methods to isolate and manipulate the complex microbial enzymes that make natural products, unexpected chemistry has been revealed and interest in the compounds has again flowered. This two-volume treatment of the subject will showcase the most important chemical classes of complex natural products: the peptides, made by the assembly of short chains of amino acid subunits, and the polyketides, assembled from the joining of small carboxylic acids such as acetate and malonate. In both classes, variation in sub-unit structure, number and chemical modification leads to an almost infinite variety of final structures, accounting for the huge importance of the compounds in nature and medicine. 350 pp. Englisch. Seller Inventory # 9780123745880

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DAVID A. HOPWOOD
Published by Academic Press (2009)
ISBN 10: 0123745888 ISBN 13: 9780123745880
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Book Description Gebunden. Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Intends to showcase the important chemical classes of complex natural products: the peptides, made by the assembly of short chains of amino acid subunits, and the polyketides, assembled from the joining of small carboxylic acids such as acetate and malonate. Seller Inventory # 594357214

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Published by Elsevier Science (2009)
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Book Description Buch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Microbial natural products have been an important traditional source of valuable antibiotics and other drugs but interest in them waned in the 1990s when big pharma decided that their discovery was no longer cost-effective and concentrated instead on synthetic chemistry as a source of novel compounds, often with disappointing results. Moreover understanding the biosynthesis of complex natural products was frustratingly difficult. With the development of molecular genetic methods to isolate and manipulate the complex microbial enzymes that make natural products, unexpected chemistry has been revealed and interest in the compounds has again flowered. This two-volume treatment of the subject will showcase the most important chemical classes of complex natural products: the peptides, made by the assembly of short chains of amino acid subunits, and the polyketides, assembled from the joining of small carboxylic acids such as acetate and malonate. In both classes, variation in sub-unit structure, number and chemical modification leads to an almost infinite variety of final structures, accounting for the huge importance of the compounds in nature and medicine. Seller Inventory # 9780123745880

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