A Pharmacology Primer: Theory, Application and Methods: Theory, Applicaton and Methods

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9780123745859: A Pharmacology Primer: Theory, Application and Methods: Theory, Applicaton and Methods

This successful guide assists scientists trained in molecular biology and related fields who now need to know the basic theories, principles and practical applications of pharmacology. This latest edition continues the tradition of better preparing researchers in the basics of pharmacology. With expanded hands-on exercises and the addition of Pharmacokinetics coverage, new human interest material including historical facts in pharmacology and a new section on therapeutics that will help readers identify with diseases and drug treatments. The ideal book for researchers in drug discovery who have seen their role shift from 'individual' to 'team player' where that team includes chemists, biologists, and others with strong, but varied, science backgrounds who must now work together toward their common pharmacology goal.At GlaxoSmithKline, a pharmaceuticals world-leader, Terry Kenakin regularly teaches a course for their research scientists and has drawn on his experience to create a pharmacology primer. Features of this title are as mentioned below. New - this part contains latest coverage of the chemistry of drugs including expanded coverage of the pharmacokinetic discussion of druglike properties that increases reader understanding of necessary ADME (Absorption, Distribution, Metabolism, and Excretion) properties and increases the rate of drug approval and acceptance. Context - this part features unique discussions on various drug discovery teams and the role of the chemist on those teams and promotes the understanding of these expanding roles and responsibilities and how to maximize the effective contributions of each matrix team member.Real-world learning - there are hands-on exercises, with extensive answers, utilizing real data on structure activity relationships as well as utilization of pharmacological principles to make general statements about how changes in structure lead to changes in drug activity. There are hands on exercises with extensive answers on Pharmacokinetics and this part strengthens practical application and understanding of core concepts and principles. Study sections are organized with ASPET (American Society for Pharmacology and Experimental Therapeutics) and other international organizations - this part ensures that learning follows professional industry standards.

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"This edition adds solid overviews of emerging topics in the field...which keep it at the cutting edge of receptor pharmacology...a valuable resource for students of pharmacology and all members of drug discovery and design teams. Rating: 4 Stars"--Doody's.com, 19-Sep-14 ".a major strength of the present monograph is the author's long-standing commitment to the didactic promotion of the discipline of pharmacology as the primary, unifying discipline of drug discovery. This monograph remains the key reference work in pharmacology and receptor theory, providing an irreplaceable yet accessible reference source for all scientists involved in biomedical research as it pertains to drug discovery. --Drug Development Research, June 27, 2014 "A wonderful contribution to the world of pharmacology that takes the reader from introductory information to advanced receptor theory. This book will be useful to both students and seasoned researchers alike. Beautifully illustrated and clearly written, this book is a welcome addition to every library." -P Michael Conn, PhD, Senior Vice President for Research and Associate Provost, Professor of Internal Medicine, School of Medicine, Professor of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX

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By Terry Kenakin

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