"ABC Proteins" is an in-depth, up-to-date analysis of all that is known about the subject to date. It discusses and compares evolution, biology and mechanism of action of all known ABC proteins, including the first structural studies as well as clinical implications. It will be useful to anyone trying to stay abreast of the latest findings. This book is sure to become a classic and will regularly be updated. Its key features include: Phylogeny and Evolution of ABC Transporters; Fundamental Aspects of the Mechanism of Action of ABC Transporters; Prokaryote ABC Transporters; Non-Mammalian Transporters; Multidrug Transporters; ABC Transporters, Physiological Roles and Human Disease; and full color throughout.
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"...the volume unquestionably succeeds overall as an in-depth survey of both the biology and the biochemistry of a ubiquitous and astonishingly diverse family of very complex enzymes. Every group with an interest in these proteins should own a copy." -CELL (July 2003) "The editors of ABC Proteins: From Bacteria to Man have valiantly attempted to encompass in this volume the entire scope of research on these proteins, from atomic-resolution structure to human genetic diseases, and from Escherichia coli to Homo sapiens and Arabidopsis thaliana... What the book makes obvious is that nearly all ABC proteins are membrane localized, ATP dependent, primary active transporters...In addition to advances in our understanding of ABC transporter structure, several chapters in the book also describe progress that has been made in elcuidating the mechanisms of transport. The volume unquestionably succeeds overall as an in-depth survey of both the biology and the biochemistry of a ubiquitous and astoundingly diverse family of very complex enzymes. Every group with an interest in these proteins should own a copy. Finally, this book makes a convincing case that many laboratories that may not yet suspect it will soon have a much more abiding interest in ABC proteins." "...well organized and included beautifully clear color images and figures." -E STREAMS (July 2003)About the Author:
By I Barry Holland
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