Three-Dimensional Electronic Microscopy of Macromolecular Assemblies is the first systematic introduction to single particle methods for reconstruction. It covers correlation alignment, classification, 3-D reconstruction, restoration, and interpretation of the resulting 3-D images oif macromolecular assemblies. It will be an indispensable resource for newcomers to the field and for all using or adopting these methods. Features: * Presents methods that offer an alternative to crystallographic techniques for molecules that cannot be crystallized * Describes methods that have been instrumental in exploring the three-dimensional structure of the nuclear pore complex, the calcium release channel,the ribosome, Chaperonins.
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Joachim Frank is an Investigator at the Howard Hughes Medical Institute. He is also Professor of Biomedical Sciences and Adjunct Professor of Biology at the State University of New York at Albany, Adjunct Professor of Biochemistry and Molecular Biophysics at Columbia University, Research Professor of Cell Biology at New York State University Medical School, and head of the Laboratory of Computational Biology and Macromolecular Imaging at Health Research, Inc., the Wadsworth Center.
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Book Description Academic Press, 1996. Hardcover. Book Condition: New. Bookseller Inventory # P110122650409