Principles of Asymmetric Synthesis, Volume 14 (Tetrahedron Organic Chemistry)

0 avg rating
( 0 ratings by Goodreads )
 
9780080418759: Principles of Asymmetric Synthesis, Volume 14 (Tetrahedron Organic Chemistry)

The world is chiral. Most of the molecules in it are chiral, and asymmetric synthesis is an important means by which enantiopure chiral molecules may be obtained for study and sale. Using examples from the literature of asymmetric synthesis (more than 1300 references), the aim of this book is to present a detailed analysis of the factors that govern stereoselectivity in organic reactions. It is important to note that the references were each individually checked by the authors to verify relevance to the topics under discussion.

The study of stereoselectivity has evolved from issues of diastereoselectivity, through auxiliary-based methods for the synthesis of enantiomerically pure compounds (diastereoselectivity followed by separation and auxiliary cleavage), to asymmetric catalysis. In the latter instance, enantiomers (not diastereomers) are the products, and highly selective reactions and modern purification techniques allow preparation - in a single step - of chiral substances in 99% ee for many reaction types.

After an explanation of the basic physical-organic principles of stereoselectivity, the authors provide a detailed, annotated glossary of stereochemical terms. A chapter on "Analytical Methods" provides a critical overview of the most common methods for analysis of stereoisomers.

The authors then follow the 'tried-and-true' format of grouping the material by reaction type. Thus, there are four chapters on carbon-carbon bond forming reactions (enolate alkylations, organometal additions to carbonyls, aldol and Michael reactions, and cycloadditions and rearrangements), one chapter on reductions and hydroborations (carbon-hydrogen bond forming reactions), and one on oxidations (carbon-oxygen and carbon-nitrogen bond forming reactions). Leading references are provided to natural product synthesis that have been accomplished using a given reaction as a key step.

In addition to tables of examples that show high selectivity, a transition state analysis is presented to explain - to the current level of understanding - the stereoselectivity of each reaction. In one case (Cram's rule) the evolution of the current theory is detailed from its first tentative (1952) postulate to the current Felkin-Anh-Heathcock formalism. For other reactions, only the currently accepted rationale is presented. Examination of these rationales also exposes the weaknesses of current theories, in that they cannot always explain the experimental observations. These shortcomings provide a challenge for future mechanistic investigations.

"synopsis" may belong to another edition of this title.

Top Search Results from the AbeBooks Marketplace

1.

Robert E. Gawley, J. Aube
Published by ELSEVIER SCIENCE TECHNOLOGY, Netherlands (2004)
ISBN 10: 0080418759 ISBN 13: 9780080418759
New Paperback Quantity Available: 10
Seller
Book Depository hard to find
(London, United Kingdom)
Rating
[?]

Book Description ELSEVIER SCIENCE TECHNOLOGY, Netherlands, 2004. Paperback. Book Condition: New. annotated edition. Language: English . This book usually ship within 10-15 business days and we will endeavor to dispatch orders quicker than this where possible. Brand New Book. The world is chiral. Most of the molecules in it are chiral, and asymmetric synthesis is an important means by which enantiopure chiral molecules may be obtained for study and sale. Using examples from the literature of asymmetric synthesis (more than 1300 references), the aim of this book is to present a detailed analysis of the factors that govern stereoselectivity in organic reactions. It is important to note that the references were each individually checked by the authors to verify relevance to the topics under discussion. The study of stereoselectivity has evolved from issues of diastereoselectivity, through auxiliary-based methods for the synthesis of enantiomerically pure compounds (diastereoselectivity followed by separation and auxiliary cleavage), to asymmetric catalysis. In the latter instance, enantiomers (not diastereomers) are the products, and highly selective reactions and modern purification techniques allow preparation - in a single step - of chiral substances in 99 ee for many reaction types. After an explanation of the basic physical-organic principles of stereoselectivity, the authors provide a detailed, annotated glossary of stereochemical terms. A chapter on Analytical Methods provides a critical overview of the most common methods for analysis of stereoisomers. The authors then follow the tried-and-true format of grouping the material by reaction type. Thus, there are four chapters on carbon-carbon bond forming reactions (enolate alkylations, organometal additions to carbonyls, aldol and Michael reactions, and cycloadditions and rearrangements), one chapter on reductions and hydroborations (carbon-hydrogen bond forming reactions), and one on oxidations (carbon-oxygen and carbon-nitrogen bond forming reactions). Leading references are provided to natural product synthesis that have been accomplished using a given reaction as a key step. In addition to tables of examples that show high selectivity, a transition state analysis is presented to explain - to the current level of understanding - the stereoselectivity of each reaction. In one case (Cram s rule) the evolution of the current theory is detailed from its first tentative (1952) postulate to the current Felkin-Anh-Heathcock formalism. For other reactions, only the currently accepted rationale is presented. Examination of these rationales also exposes the weaknesses of current theories, in that they cannot always explain the experimental observations. These shortcomings provide a challenge for future mechanistic investigations. Bookseller Inventory # EOD9780080418759

More Information About This Seller | Ask Bookseller a Question

Buy New
£ 34.35
Convert Currency

Add to Basket

Shipping: FREE
From United Kingdom to U.S.A.
Destination, Rates & Speeds

2.

Robert E. Gawley, J. Aube
Published by ELSEVIER SCIENCE TECHNOLOGY, Netherlands (2004)
ISBN 10: 0080418759 ISBN 13: 9780080418759
New Paperback Quantity Available: 10
Print on Demand
Seller
The Book Depository
(London, United Kingdom)
Rating
[?]

Book Description ELSEVIER SCIENCE TECHNOLOGY, Netherlands, 2004. Paperback. Book Condition: New. annotated edition. Language: English . Brand New Book ***** Print on Demand *****.The world is chiral. Most of the molecules in it are chiral, and asymmetric synthesis is an important means by which enantiopure chiral molecules may be obtained for study and sale. Using examples from the literature of asymmetric synthesis (more than 1300 references), the aim of this book is to present a detailed analysis of the factors that govern stereoselectivity in organic reactions. It is important to note that the references were each individually checked by the authors to verify relevance to the topics under discussion. The study of stereoselectivity has evolved from issues of diastereoselectivity, through auxiliary-based methods for the synthesis of enantiomerically pure compounds (diastereoselectivity followed by separation and auxiliary cleavage), to asymmetric catalysis. In the latter instance, enantiomers (not diastereomers) are the products, and highly selective reactions and modern purification techniques allow preparation - in a single step - of chiral substances in 99 ee for many reaction types. After an explanation of the basic physical-organic principles of stereoselectivity, the authors provide a detailed, annotated glossary of stereochemical terms. A chapter on Analytical Methods provides a critical overview of the most common methods for analysis of stereoisomers. The authors then follow the tried-and-true format of grouping the material by reaction type. Thus, there are four chapters on carbon-carbon bond forming reactions (enolate alkylations, organometal additions to carbonyls, aldol and Michael reactions, and cycloadditions and rearrangements), one chapter on reductions and hydroborations (carbon-hydrogen bond forming reactions), and one on oxidations (carbon-oxygen and carbon-nitrogen bond forming reactions). Leading references are provided to natural product synthesis that have been accomplished using a given reaction as a key step. In addition to tables of examples that show high selectivity, a transition state analysis is presented to explain - to the current level of understanding - the stereoselectivity of each reaction. In one case (Cram s rule) the evolution of the current theory is detailed from its first tentative (1952) postulate to the current Felkin-Anh-Heathcock formalism. For other reactions, only the currently accepted rationale is presented. Examination of these rationales also exposes the weaknesses of current theories, in that they cannot always explain the experimental observations. These shortcomings provide a challenge for future mechanistic investigations. Bookseller Inventory # AAV9780080418759

More Information About This Seller | Ask Bookseller a Question

Buy New
£ 36.94
Convert Currency

Add to Basket

Shipping: FREE
From United Kingdom to U.S.A.
Destination, Rates & Speeds

3.

Gawley, R, E
Published by Elsevier (2016)
ISBN 10: 0080418759 ISBN 13: 9780080418759
New Paperback Quantity Available: 1
Print on Demand
Seller
Ria Christie Collections
(Uxbridge, United Kingdom)
Rating
[?]

Book Description Elsevier, 2016. Paperback. Book Condition: New. PRINT ON DEMAND Book; New; Publication Year 2016; Not Signed; Fast Shipping from the UK. No. book. Bookseller Inventory # ria9780080418759_lsuk

More Information About This Seller | Ask Bookseller a Question

Buy New
£ 36.52
Convert Currency

Add to Basket

Shipping: £ 3.87
From United Kingdom to U.S.A.
Destination, Rates & Speeds

4.

Gawley, R.E.
Published by Pergamon (1996)
ISBN 10: 0080418759 ISBN 13: 9780080418759
New Quantity Available: > 20
Print on Demand
Seller
Books2Anywhere
(Fairford, GLOS, United Kingdom)
Rating
[?]

Book Description Pergamon, 1996. PAP. Book Condition: New. New Book. Delivered from our UK warehouse in 3 to 5 business days. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000. Bookseller Inventory # LQ-9780080418759

More Information About This Seller | Ask Bookseller a Question

Buy New
£ 31.56
Convert Currency

Add to Basket

Shipping: £ 9.01
From United Kingdom to U.S.A.
Destination, Rates & Speeds

5.

Robert E. Gawley, J. Aube
Published by ELSEVIER SCIENCE TECHNOLOGY, Netherlands (2004)
ISBN 10: 0080418759 ISBN 13: 9780080418759
New Paperback Quantity Available: 10
Print on Demand
Seller
The Book Depository US
(London, United Kingdom)
Rating
[?]

Book Description ELSEVIER SCIENCE TECHNOLOGY, Netherlands, 2004. Paperback. Book Condition: New. annotated edition. Language: English . Brand New Book ***** Print on Demand *****. The world is chiral. Most of the molecules in it are chiral, and asymmetric synthesis is an important means by which enantiopure chiral molecules may be obtained for study and sale. Using examples from the literature of asymmetric synthesis (more than 1300 references), the aim of this book is to present a detailed analysis of the factors that govern stereoselectivity in organic reactions. It is important to note that the references were each individually checked by the authors to verify relevance to the topics under discussion. The study of stereoselectivity has evolved from issues of diastereoselectivity, through auxiliary-based methods for the synthesis of enantiomerically pure compounds (diastereoselectivity followed by separation and auxiliary cleavage), to asymmetric catalysis. In the latter instance, enantiomers (not diastereomers) are the products, and highly selective reactions and modern purification techniques allow preparation - in a single step - of chiral substances in 99 ee for many reaction types. After an explanation of the basic physical-organic principles of stereoselectivity, the authors provide a detailed, annotated glossary of stereochemical terms. A chapter on Analytical Methods provides a critical overview of the most common methods for analysis of stereoisomers. The authors then follow the tried-and-true format of grouping the material by reaction type. Thus, there are four chapters on carbon-carbon bond forming reactions (enolate alkylations, organometal additions to carbonyls, aldol and Michael reactions, and cycloadditions and rearrangements), one chapter on reductions and hydroborations (carbon-hydrogen bond forming reactions), and one on oxidations (carbon-oxygen and carbon-nitrogen bond forming reactions). Leading references are provided to natural product synthesis that have been accomplished using a given reaction as a key step. In addition to tables of examples that show high selectivity, a transition state analysis is presented to explain - to the current level of understanding - the stereoselectivity of each reaction. In one case (Cram s rule) the evolution of the current theory is detailed from its first tentative (1952) postulate to the current Felkin-Anh-Heathcock formalism. For other reactions, only the currently accepted rationale is presented. Examination of these rationales also exposes the weaknesses of current theories, in that they cannot always explain the experimental observations. These shortcomings provide a challenge for future mechanistic investigations. Bookseller Inventory # AAV9780080418759

More Information About This Seller | Ask Bookseller a Question

Buy New
£ 41.11
Convert Currency

Add to Basket

Shipping: FREE
From United Kingdom to U.S.A.
Destination, Rates & Speeds

6.

Gawley, R.E.
Published by Pergamon (1996)
ISBN 10: 0080418759 ISBN 13: 9780080418759
New Quantity Available: > 20
Print on Demand
Seller
Pbshop
(Wood Dale, IL, U.S.A.)
Rating
[?]

Book Description Pergamon, 1996. PAP. Book Condition: New. New Book. Shipped from US within 10 to 14 business days. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000. Bookseller Inventory # IQ-9780080418759

More Information About This Seller | Ask Bookseller a Question

Buy New
£ 39.98
Convert Currency

Add to Basket

Shipping: £ 3.06
Within U.S.A.
Destination, Rates & Speeds

7.

Gawley, R.E., Aubé, J.
Published by Pergamon (2017)
ISBN 10: 0080418759 ISBN 13: 9780080418759
New Paperback Quantity Available: 2
Print on Demand
Seller
Murray Media
(North Miami Beach, FL, U.S.A.)
Rating
[?]

Book Description Pergamon, 2017. Paperback. Book Condition: New. This item is printed on demand. Bookseller Inventory # P110080418759

More Information About This Seller | Ask Bookseller a Question

Buy New
£ 45.34
Convert Currency

Add to Basket

Shipping: £ 2.30
Within U.S.A.
Destination, Rates & Speeds

8.

Gawley, R.E.; Aubé, J.
Published by Pergamon
ISBN 10: 0080418759 ISBN 13: 9780080418759
New PAPERBACK Quantity Available: 1
Seller
Cloud 9 Books
(Wellington, FL, U.S.A.)
Rating
[?]

Book Description Pergamon. PAPERBACK. Book Condition: New. 0080418759 New Condition. Bookseller Inventory # NEW6.3014921

More Information About This Seller | Ask Bookseller a Question

Buy New
£ 47.43
Convert Currency

Add to Basket

Shipping: £ 3.83
Within U.S.A.
Destination, Rates & Speeds

9.

R.E. Gawley, J. Aubé
Published by Pergamon (2004)
ISBN 10: 0080418759 ISBN 13: 9780080418759
New Paperback Quantity Available: 1
Seller
Ergodebooks
(RICHMOND, TX, U.S.A.)
Rating
[?]

Book Description Pergamon, 2004. Paperback. Book Condition: New. 1. Bookseller Inventory # DADAX0080418759

More Information About This Seller | Ask Bookseller a Question

Buy New
£ 50.07
Convert Currency

Add to Basket

Shipping: £ 3.06
Within U.S.A.
Destination, Rates & Speeds

10.

Gawley, R.E.
Published by Pergamon (2017)
ISBN 10: 0080418759 ISBN 13: 9780080418759
New Paperback Quantity Available: 15
Print on Demand
Seller
Murray Media
(North Miami Beach, FL, U.S.A.)
Rating
[?]

Book Description Pergamon, 2017. Paperback. Book Condition: New. This item is printed on demand. Bookseller Inventory # 0080418759

More Information About This Seller | Ask Bookseller a Question

Buy New
£ 51.72
Convert Currency

Add to Basket

Shipping: £ 2.30
Within U.S.A.
Destination, Rates & Speeds

There are more copies of this book

View all search results for this book