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RNA Technologies and Their Applications

Published by Springer-Verlag Gmbh Sep 2010, 2010
ISBN 10: 3642121675 / ISBN 13: 9783642121678
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Title: RNA Technologies and Their Applications

Publisher: Springer-Verlag Gmbh Sep 2010

Publication Date: 2010

Binding: Buch

Book Condition: Neu


Neuware - Innovation in biotechnology that combine molecular biology, cell biology, microfabrication and bioinformatics are moving nucleic acid technologies from futuristic possibilities into common laboratory and clinical procedures. They have potential to revolutionize biomedical research and medicine. Three variants of RNA technologies are known, namely antisense oligonucleotides, RNA interference, and ribozymes. In spite of different mechanisms of action, all of them are united by the common principle: an antisense preparation works after binding with RNA-target by forming a duplex. Today all three approaches are intensively used in vivo. RNA mediated gene silencing is a powerful technology to downregulate the expression of targeted genes within the cell. Now RNA interference based therapeutics is to be released. This book provides a state-of-the-art review concerning the molecular basis as well as applications of RNA based technologies in molecular biology and medicine. 451 pp. Englisch. Bookseller Inventory # 9783642121678

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Synopsis: RNA technologies are the driving forces of modern medicine and biotechnology. They combine the fields of biochemistry, chemistry, molecular biology, cell biology, physics, nanotechnology and bioinformatics. The combination of these topics is set to revolutionize the medicine of tomorrow. After more than 15 years of extensive research in the field of RNA technologies, the first therapeutics are ready to reach the first patients. Thus we are witnessing the birth of a very exciting time in the development of molecular medicine, which will be based on the methods of RNA technologies. This volume is the first of a series. It covers various aspects of RNA interference and microRNAs, although antisense RNA applications, hammerhead ribozyme structure and function as well as non-coding RNAs are also discussed. The authors are internationally highly respected experts in the field of RNA technologies.

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