Review:
..".the text of the volume has been well organized giving appropriate tables, figures in depth and comprehensive manner, covering important and novel issues."
- Prof P.K.Gupta, Adviser to WHO and Director TCS Inc., Bareilly, India for TOXICOLOGY INTERNATIONAL (June 2006)
From the Back Cover:
This book brings together the expertise of leading scientists from around the world on the complex toxicology of anticholinesterase compounds (Organophosphates and Carbamates) . It provides the most up-to-date and in-depth knowledge on various aspects of OP and CM compounds, including their use, classification, mechanism-based toxicity, and prophylactic and therapeutic measurements
Anticholinesterase compounds constitute the largest number of chemicals that are primarily used as insecticides in agriculture, industry, and around the home/garden. Some OPs (nerve agents) have been used both in chemical warfare and terrorist attacks; while other OPs and CMs have been recommended as therapeutic agents in human and veterinary medicine.
Many chemicals of both classes are extremely toxic and lack selectivity, thus their inadvertent and accidental use continues to pose a threat to human and animal health, aquatic systems, and wildlife. These anticholinesterase agents produce a variety of toxicological effects in target and non-target organs. These are some of the contributing factors that make this class of agents so very important and will make this book a crucial reference work for every researcher dealing with these agents.
Extensively covers pesticides, nerve agents, therapeutic drugs, and flame retardants
Describes epidemiology of the world s major disasters involving Organophosphates and Carbamates
Covers animal, human, aquatic, and wildlife toxicity of Anticholinesterases
Insights into in-depth cholinergic and noncholinergic mechanisms of toxicity
Describes recent advancements in cholinesterases, paraoxonases, carboxylesterases, oxidative stress, endocrine disruption, cardiac and pulmonary toxicity, and carcinogenesis
Provides in vitro and in vivo models for neurotoxicity testing
Integrates knowledge of studies in lab animals and humans
Offers risk/safety assessment and national/international guidelines for permissible levels of pesticide residues
Describes management of Anticholinesterase poisoning in humans|This book brings together the expertise of leading scientists from around the world on the complex toxicology of anticholinesterase compounds (Organophosphates and Carbamates) . It provides the most up-to-date and in-depth knowledge on various aspects of OP and CM compounds, including their use, classification, mechanism-based toxicity, and prophylactic and therapeutic measurements
Anticholinesterase compounds constitute the largest number of chemicals that are primarily used as insecticides in agriculture, industry, and around the home/garden. Some OPs (nerve agents) have been used both in chemical warfare and terrorist attacks; while other OPs and CMs have been recommended as therapeutic agents in human and veterinary medicine.
Many chemicals of both classes are extremely toxic and lack selectivity, thus their inadvertent and accidental use continues to pose a threat to human and animal health, aquatic systems, and wildlife. These anticholinesterase agents produce a variety of toxicological effects in target and non-target organs. These are some of the contributing factors that make this class of agents so very important and will make this book a crucial reference work for every researcher dealing with these agents.
Extensively covers pesticides, nerve agents, therapeutic drugs, and flame retardants
Describes epidemiology of the world s major disasters involving Organophosphates and Carbamates
Covers animal, human, aquatic, and wildlife toxicity of Anticholinesterases
Insights into in-depth cholinergic and noncholinergic mechanisms of toxicity
Describes recent advancements in cholinesterases, paraoxonases, carboxylesterases, oxidative stress, endocrine disruption, cardiac and pulmonary toxicity, and carcinogenesis
Provides in vitro and in vivo models for neurotoxicity testing
Integrates knowledge of studies in lab animals and humans
Offers risk/safety assessment and national/international guidelines for permissible levels of pesticide residues
Describes management of Anticholinesterase poisoning in humans
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