The Epigenome and Developmental Origins of Health and Disease - Softcover

Softcover

ISBN 10: 0128013834 ISBN 13: 9780128013830

Publisher: Academic Press, 2015

Synopsis

The Epigenome and Developmental Origins of Health and Disease synthesizes the existing knowledge on how the in utero environment could be the most important environment in shaping later risk for various diseases or to conversely promote the health of the offspring. The book mines the existing literature from a variety of disciplines from toxicology to nutrition to epigenetics to reveal how contrasting maternal in utero environmental changes might be leading to epigenetic convergence and the resulting deleterious phenotypic and physiological effects in our offspring. It is increasingly becoming apparent that even subtle changes in the mother's diet, stress, and exposure to low concentrations of toxic chemicals at levels deemed safe by the EPA and FDA, such as endocrine disrupting compounds (EDC), can dramatically impact the health of our children, possibly leading to metabolic, cardiovascular, immunological, neurobehavioral disorders, and increased risk for cancer to list but a few examples. * Informs how everyday choices pregnant women make can impact child development* Ties together how in utero environmental changes may be inducing epigenetic changes in the offspring leading to overlapping phenotypes regardless of the initial insult (toxic, nutrition, or stress)* Includes a boxed-in area in each chapter for further references and resources to keep up with the field* Features video interviews with the authors and other key leaders in the field

About this title

Review:

This book reveals how contrasting in utero environmental changes may be leading to epigenetic convergence that result in deleterious phenotypic and physiological effects in offspring, synthesizing the existing knowledge on how the in utero environment could be the most important environment in shaping later risk for various diseases.

About the Author:

Dr. Rosenfeld has published extensively on how maternal diet and developmental exposure to endocrine disrupting compounds, including bisphenol A (BPA) and ethinyl estradiol (EE) affect offspring outcomes, such as neurobehavioral disruptions. She has been continually funded through the National Institutes of Health, including National Cancer Institute, National Institute of Child Health and Development (NICHD) and National Institute of Environmental Health and Sciences (NIEHS) for this work on developmental origins of health and disease. She has written several review articles and book chapters, including the most recent one on “Animal Models of Transgenerational Effects in TRANSGENERATIONAL EPIGENETICS: Evidence and Debate, to be published by Elsevier.

About this edition

• Publisher: Academic Press
• Publication date: 2015
• ISBN 10: 0128013834
• ISBN 13: 9780128013830
• Binding: Paperback
• Number of pages: 560
• Editor: Rosenfeld Cheryl S.