Research on the nuclear matrix has grown enormously since Bereney and Coffey first reported its isolation and initial characterization in 1974. Since then, more than 1000 papers have been published on the subject by numerous workers around the world. This is the first book devoted to reviewing the major developments in this growing field. The chapters cover a variety of topics, including: Isolation of the nuclear matrix; Nuclear structure morphology in situ; Structural domains of the nuclear matrix and its components; Biochemistry and molecular biology of the matrix proteins and associated DNA and RNA; Functional properties associated with the nuclear matrix; DNA replication; Transcription; RNA splicing; Transcription regulation; Intranuclear and nucleocytoplasmic transport and targeting; and Cell cycle regulation.
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"A valuable addition to any college library as current reference material for advanced undergraduates, graduate students, and professional scientists." -- Choice
"In keeping with the high standards set by the editors...carefully prepared and edited in the customary fine format and well-illustrated style of Academic Press publications...this series is a significant contribution to a science that impinges on many fields." -- The Quarterly Review of Biology
"Maintains the tradition and set-up of the previous volumes and certainly provides up-to-date data on varied aspects of cytology...a valuable acquisition to any library." -- The Nucleus
Praise for the Series "Invaluable reading for all biologists." -- Nature
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