Physiology and Pathology of chloride transporters and channels in the nervous system: From Molecules to Diseases - Hardcover

Alvarez-Leefmans, F.

Hardcover

ISBN 10: 0123743737 ISBN 13: 9780123743732

Publisher: Academic Press, 2009

Synopsis

The importance of chloride ions in cell physiology has not been fully recognized until recently, in spite of the fact that chloride (Cl-), together with bicarbonate, is the most abundant free anion in animal cells, and performs or determines fundamental biological functions in all tissues. For many years it was thought that Cl- was distributed in thermodynamic equilibrium across the plasma membrane of most cells. Research carried out during the last couple of decades has led to a dramatic change in this simplistic view. We now know that most animal cells, neurons included, exhibit a non-equilibrium distribution of Cl- across their plasma membranes. Over the last 10 to 15 years, with the growth of molecular biology and the advent of new optical methods, an enormous amount of exciting new information has become available on the molecular structure and function of Cl- channels and carriers. In nerve cells, Cl- channels and carriers play key functional roles in GABA- and glycine-mediated synaptic inhibition, neuronal growth and development, extracellular potassium scavenging, sensory-transduction, neurotransmitter uptake and cell volume control. Disruption of Cl- homeostasis in neurons underlies pathological conditions such as epilepsy, deafness, imbalance, brain edema and ischemia, pain and neurogenic inflammation. This book is about how chloride ions are regulated and how they cross the plasma membrane of neurons. It spans from molecular structure and function of carriers and channels involved in Cl- transport to their role in various diseases.

* The first comprehensive book on the structure, molecular biology, cell physiology, and role in diseases of chloride transporters / channels in the nervous system in almost 20 years
* Chloride is the most abundant free anion in animal cells. THis book summarizes and integrates for the first time the important research of the past two decades that has shown that Cl- channels and carriers play key functional roles in GABA- and glycine-mediated synaptic inhibition, neuronal growth and development, extracellular potassium scavenging, sensory-transduction, neurotransmitter uptake and cell volume control.
* The first book that systematically discusses the result of disruption of Cl- homeostasis in neurons which underlies pathological conditions such as epilepsy, deafness, imbalance, brain edema and ischemia, pain and neurogenic inflammation.
* Spanning topics from molecular structure and function of carriers and channels involved in Cl- transport to their role in various diseases.
* Involves all of the leading researchers in the field.
* INcludes an extensive introductory section that covers basic thermodynamic and kinetics aspects of Cl- transport, as well as current methods for studying Cl- regulation, spanning from fluorescent dyes in single cells to knock-out models to make the book available for a growing population of graduate students and postdocs entering the field.

About this title

Review:

The first comprehensive book on the molecular structure and function of chloride transporters and channels and their impact on various neurological diseases in almost 20 years

From the Back Cover:

Chloride ions play a key role in the nervous system. They are integral to functions such as synaptic inhibition, neuronal development, sensory transduction and homeostasis of brain fluids and electrolytes. Over the last 10 to 15 years the spectacular growth of molecular biology and the advent of new optical and electrophysiological methods have resulted in exciting new information about the molecular structure and function of chloride channels and carriers and their involvement in various diseases. Chloride transport proteins have become potential pharmacological targets for the treatment of conditions as diverse as epilepsy, pain, neurogenic inflammation, tumor growth and invasion, and brain edema.

This is the first book to provide a coherent and comprehensive review of our current knowledge of the mechanisms by which chloride ions cross the membranes of nerve, glial and epithelial cells. Each chapter presents fundamental concepts and detailed information about the molecular structure and function of carriers and channels involved in chloride transport, as well as discussion of their role in various neurological diseases. Authors identify areas where more work is needed within this exponentially expanding field of cellular and molecular neurobiology, and provide extensive information on state-of-the-art methods available for studying chloride transport and regulation.

 

 

• Written by recognized leading experts, and carefully edited and cross-referenced to provide a coherent presentation

• Illustrated with high quality color drawings and photographs

• Integrates emerging concepts in the field of chloride transporters and channels, from molecules to diseases

• A valuable resource for researchers in neuroscience, molecular and cell biology, and for non-specialists wishing to enter the field

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Chloride ions play a key role in the nervous system. They are integral to functions such as synaptic inhibition, neuronal development, sensory transduction and homeostasis of brain fluids and electrolytes. Over the last 10 to 15 years the spectacular growth of molecular biology and the advent of new optical and electrophysiological methods have resulted in exciting new information about the molecular structure and function of chloride channels and carriers and their involvement in various diseases. Chloride transport proteins have become potential pharmacological targets for the treatment of conditions as diverse as epilepsy, pain, neurogenic inflammation, tumor growth and invasion, and brain edema.

This is the first book to provide a coherent and comprehensive review of our current knowledge of the mechanisms by which chloride ions cross the membranes of nerve, glial and epithelial cells. Each chapter presents fundamental concepts and detailed information about the molecular structure and function of carriers and channels involved in chloride transport, as well as discussion of their role in various neurological diseases. Authors identify areas where more work is needed within this exponentially expanding field of cellular and molecular neurobiology, and provide extensive information on state-of-the-art methods available for studying chloride transport and regulation.

• Written by recognized leading experts, and carefully edited and cross-referenced to provide a coherent presentation

• Illustrated with high quality color drawings and photographs

• Integrates emerging concepts in the field of chloride transporters and channels, from molecules to diseases

• A valuable resource for researchers in neuroscience, molecular and cell biology, and for non-specialists wishing to enter the field

About this edition

• Publisher: Academic Press
• Publication date: 2009
• ISBN 10: 0123743737
• ISBN 13: 9780123743732
• Binding: Hardcover
• Number of pages: 500
• Editor: F. Javier Alvarez-Leefmans, Eric Delpire